Where to watch Serie A, odds, live stream, schedule: Juventus vs. Napoli, Inter vs. AC Milan on Sunday

The 2024-25 Serie A season is back and back with a bang as the usual giants aim to fight for the title, while other clubs hope they can pull off what Bologna did last season and surprisingly qualify for the Champions League. Inter and Juventus look like the favorites to win the league on paper, but teams like AC Milan and Atalanta hope to spoil the party in what should be another thrilling campaign. 

Game of the week: Inter vs. AC Milan 

The most anticipated clash of the season is happening this weekend and it has huge implications, especially after UEFA Champions League matches this week. AC Milan’s manager Paulo Fonseca has his last chance to keep his job after a poor start of the season, and it’s possible only a win against their city rivals can save him, with names such as Maurizio Sarri and Thomas Tuchel already mentioned as potential replacements. Inter, on the other hand, drew against Monza away in the last game, but then impressed and drew on the road against Manchester City on Wednesday. Will Inter win their seventh Derby della Madonnina in a row against the Rossoneri and mark the end of the Fonseca era? 

• Date: Sunday, Sept. 22 | Time: 2:45 p.m. ET
• Location: San Siro — Milan, Italy
• Live stream: Paramount+
• Odds: Inter -155; Draw +300; AC Milan +400

Game of the week runner up: Juventus vs. Napoli

If the Derby between Inter and AC Milan wasn’t enough, Napoli will face Juventus at the Allianz Stadium on Saturday for another key game of the Scudetto race. Antonio Conte makes his comeback against the team where he was an icon and captain before becoming a manager in 2011. Napoli are currently well positioned at the top of the table, but this is their first real test against another team that started off well a new cycle under Thiago Motta. 

• Date: Saturday, Sept. 21 | Time: 12 p.m. ET
• Location: Allianz Stadium — Turin, Italy
• Live stream: Paramount+
• Odds: Juventus +115; Draw +230; Napoli +240

AS Roma’s new coach 

Lastly, it was a big week at Roma after the Giallorossi decided to sack Daniele De Rossi and appointed former Torino and Verona manager Ivan Juric, who makes his debut at the Stadio Olimpico this Sunday. A huge game after a difficult start of the season that will tell us more about how the fans welcomed the decision of the board that fired an icon of the club only a few months after extending his deal for three more years. 

• Date: Sunday, Sept. 22 | Time: 12:00 p.m. ET
• Location: Stadio Olimpico — Rome, Italy
• Live stream: Paramount+
• Odds: Roma -130; Draw +170; Udinese +425

How to watch: Matchday 4

All times U.S./Eastern

Friday, Sept. 20
Cagliari vs. Empoli, 12:30 p.m. (Paramount+/CBS Sports Golazo Net)
Verona vs. Torino, 2:45 p.m. (Paramount+ /CBS Sports Golazo Net)

Saturday, Sept. 21
Venezia vs. Genoa, 9:00 a.m. (Paramount+)
Juventus vs. Napoli, 12:00 p.m. (Paramount+)
Lecce vs. Parma, 2:45 p.m. (Paramount+)

Sunday, Sept. 22
Fiorentina vs. Lazio, 6:30 a.m. (Paramount+/CBS Sports Golazo Net)
Monza vs. Bologna, 9:00 a.m. (Paramount+/CBS Sports Golazo Net )
Roma vs. Udinese, 12:00 p.m. (Paramount+)
Inter vs. AC Milan, 2:45 p.m. (Paramount+)

Monday, Sept. 23
Atalanta vs. Como, 2:45 p.m. (Paramount+ )