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Seahawks vs. Cardinals odds, prediction, betting trends for NFL’s ‘Thursday Night Football’ game


When the Seahawks host the Cardinals in Seattle to begin NFL Week 11 on “Thursday Night Football” (8:20 p.m. ET, Fox, NFL Network, Amazon Prime Video), they will be looking for critical revenge. The Cardinals won the season’s first meeting in Arizona, 37-34 in overtime in Week 7. With both teams at 6-3, that gives the Cardinals the slight NFC West lead, with the Seahawks in third place after losing to the Rams in Week 10.

The spotlight will be on quarterbacks Russell Wilson and Kyler Murray. With mounting turnovers for Seattle, Wilson is quickly seeing his once tight grip on his first MVP award slip away. At the same time, Murray, the second-year passing and rushing sensation for Arizona, is now in the mix, trying to follow the feats of Patrick Mahomes and Lamar Jackson before him.

On the other side, it’s been a defensive struggle for both teams. So expect another high-scoring game as Wilson and Murray each look to give his team late control of the division.

Here’s how Sporting News sees the rematch playing out, plus betting information you need to know for the game:

WEEK 11 NFL PICKS: Against the spread | Straight up

Betting odds for ‘Thursday Night Football’

  • Spread: Seahawks -3
  • Point total: 57
  • Odds: Cardinals +145, Seahawks -165

The Seahawks have been the traditional field-goal home favorites since the initial lines, making this a pick ’em game on a neutral field. The Seahawks are 4-0 at home this season despite the lack of usual crowd noise. They are only 1-3 on the road.

Seahawks vs. Cardinals all-time series

With that overtime victory in Week 5, the Cardinals have evened things up for their relatively new NFC West rivalry with the Seahawks, 51-51-1. The Seahawks spent a long time in the AFC West, and the Cardinals had been in the NFC East. They have played each other twice since 2002, when the NFL went to its current eight-division format. The Cardinals have now won two in a row. Before that the Seahawks had a three-game winning streak.

Three trends to know

— 58 percent of spread bettors and 94 percent of moneyline bettors like the Seahawks at home, counting on their unblemished record in Seattle.

— 58 percent of over/under bettors think the teams will easily exceed the high point total with their explosive offenses, given more than 70 points were scored the first time in prime time.

— The Seahawks are 2-3 against the spread in their past five games. The Cardinals are 1-4 against the spread in their past five games.

MORE: Kyler Murray vs. Russell Wilson comparison is really more of a QB contrast

Three things to watch

Who’s healthy for the Seahawks?

Offensively, the Seahawks will likely be without running backs Chris Carson (foot; questionable) and Travis Homer (knee/thumb; doubtful). Carlos Hyde (hamstring) will return to help their struggling power running game, however. Wide receiver Tyler Lockett (knee; questionable), who had 15 catches for 200 yards and three touchdowns in the first meeting, is a game-time decision. Center Ethan Pocic (concussion) will miss a second consecutive game

Defensively, the Seahawks will again be missing their two top cornerbacks, Shaquill Griffin (hamstring) and Quinton Dunbar (knee). 

Will the Cardinals have a letdown?

Arizona snatched victory from the jaws of defeat when Murray completed the improbable 43-yard game-winning “Hail Mary” TD pass to top wide receiver DeAndre Hopkins against the Bills. The Cardinals have now played three straight tight, one-possession games with both teams scoring in the 30s, winning two. The Seahawks had that close shootout mojo early in the season, something they must get back in a hury.

Jamal Adams vs. Budda Baker

Two of the NFL’s best game-changing safeties are getting lost in two defenses crumbling around them. But both are capable of making big plays in key moments to lift their teams, much like Baker did with his key interception of Wilson, along with 14 tackles, in the first meeting. Adams didn’t play in Week 7. He’s returned with a bang, with 3.5 sacks the past two weeks.

MORE: The anatomy of Kyler Murray’s game-winning “Hail Mary”

Stat that matters

308: That’s how many rushing yards Murray has combined in the past four games, on 46 attempts. He’s scored five TDs in that span, extending his scoring streak on the ground to five games. The Seahawks need to find a way to contain his running, the big reason why the Cardinals have the No. 1 rushing attack in the NFL. Adams can be a factor there.

Seahawks vs. Cardinals prediction

This feels like another wild West shootout between two top quarterbacks making plays with their arms and feet. Wilson will find a way with whoever’s out there, while Murray will be up to the task for another duel. Call this as another home night game escape for Seattle on the final possession to take back first place in the division.

Seahawks 38, Cardinals 34


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