Graffiti has been scrawled across the artwork, which depicts the much-loved Manchester United forward. The indecipherable lettering, daubed in blue paint on Sunday night, can barely be seen over the powerful black and white image.
The portrait, created last November, stands across a wall in the Withington area of Manchester, not far from where the footballer grew up.
It’s the second time the same mural has been targeted by yobs in eight months, Manchester Evening News reports.
Rashford, 23, saw his penalty hit the post in the shootout last night.
But Rashford, who in the past year has been celebrated for spearheading a campaign for all children to have free school meals, received support online.
One post reads: “We were robbed. Saka, Rashford we got you – we are proud of you Raised fist @MarcusRashford @BukayoSaka87”
Another says: “People soon forget the great things someone has done just because of one mistake. They all should be proud of how far they took England, no other team has done that before.”
A third states: “Disgusting behaviour – show some respect. Players need our respect and should be applauded for their commitment.”