A friend of the family confirmed his death to the PA Media news agency on Wednesday.
The agency said it understood that Kamen — born Ivor Neville Kamen — died on Tuesday night after a long illness.
“RIP to the most beautiful and sweetest man Nick Kamen!” he wrote.
Born in Essex, southeastern England, Kamen catapulted to fame when he appeared on the cover of “The Face” magazine in 1984, wearing lipstick, aviator glasses and a ski hat.
He became a global sex symbol the following year, when he stripped down to his boxers in the memorable 1985 Levi’s 501 commercial, soundtracked by Marvin Gaye’s “I Heard It Through The Grapevine.”